Abstract Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution (SCRaMbLE) is a promising tool to study genomic rearrangements. However. the potential of SCRaMbLE to study genomic rearrangements is currently hindered. because a strain containing all 16 synthetic chromosomes is not yet available. https://goodvibesbadhabiters.shop/product-category/sc-novelties/